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A novel time-resolved fluorescence-based high-throughput screening technology for discovering allosteric kinase inhibitors


Year of Award:
2017
Status:
Complete
Award Type:
R21
Project Number:
CA217695
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LEVINSON, NICHOLAS MARK
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MINNESOTA

Allosteric kinase inhibitors are highly sought after as cancer drugs to override resistance to conventional kinaseinhibitors, a major clinical problem that severely limits the duration of response to many front-line cancertherapies. Unfortunately, most ex