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Next generation CRISPR/Cas9-RNAi mouse models for accelerated drug discovery research


Year of Award:
2017
Status:
Complete
Award Type:
R44
Project Number:
CA188154
RFA Number:
PAR-13-327
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
PREMSRIRUT, PREM KHOVABUTR
Other PI or Project Leader:
N/A
Institution:
MIRIMUS, INC.
New approaches for rapid identification and early preclinical validation of novel therapeutictargets are crucial to make important “go/no-go” decisions and curb the cost of developing new cancertreatments. Genetically engineered mouse models (GEMMs) are a