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A MOLECULAR TOOLKIT FOR THE PRODUCTION OF TYROSINE PHOSPHORYLATED PROTEINS


Year of Award:
2017
Status:
NCE
Award Type:
R21
Project Number:
CA212726
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
NAEGLE, KRISTEN M
Other PI or Project Leader:
N/A
Institution:
WASHINGTON UNIVERSITY

Tyrosine phosphorylation can regulate protein function, and this is a cornerstone of cell signaling networks. Ty-rosine phosphorylation often becomes dysregulated in cancer and therefore, understanding the effect of phos-phorylation on protein function wi