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Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass Spectrometry


Year of Award:
2017
Status:
Complete
Award Type:
R33
Project Number:
CA212973
RFA Number:
RFA-CA-16-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
YATES, JOHN R
Other PI or Project Leader:
N/A
Institution:
SCRIPPS RESEARCH INSTITUTE

Malignant transformation of cells drives the development of tumors. Cancer cells can beroutinely genotyped today revealing a large number of somatic mutations. However, it remainsunclear which mutations contribute to malignant transformation and provide a