Maximum efficiency sequencing using nuclease-based mutation enrichment and digital barcodes


Year of Award:
2017
Status:
Active
Award Type:
R33
Project Number:
CA217652
RFA Number:
RFA-CA-16-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MAKRIGIORGOS, G. MIKE
Other PI or Project Leader:
N/A
Institution:
DANA-FARBER CANCER INST
Low-level tumor somatic DNA mutations can have profound implications for development of metastasis,prognosis, choice of treatment, follow-up or early cancer detection strategies. Unless they are effectivelydetected, these low-level mutations can misinform