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The GOF Mutant p53 Beacon System


Year of Award:
2017
Status:
Complete
Award Type:
R21
Project Number:
CA212967
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WINDLE, BRAD E.
Other PI or Project Leader:
DEB, SUMITRA
Institution:
VIRGINIA COMMONWEALTH UNIVERSITY

We have developed a system in which Gain-Of-Function (GOF) mutant p53 makes living cells fluoresce andluminesce (GOF Mutant p53 Beacon System). This powerful tool allows us to instantly assess the presence orabsence of mutant p53 in living cells and is no