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Fluorescence lifetime-based single fluorophore biosensors of post-translational modification enzyme activity


Year of Award:
2017
Status:
NCE
Award Type:
R33
Project Number:
CA217780
RFA Number:
RFA-CA-16-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
PARKER, LAURIE L.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MINNESOTA

Despite decades of research on post-translational modification enzymes, little is known about their dynamic,spatiotemporal activities on a subcellular level—and yet the nature of these subcellular activities is often key tounderstanding their dysfunction