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Exquisitely selective turn-on probes of kinase activation and localization


Year of Award:
2017
Status:
NCE
Award Type:
R21
Project Number:
CA214233
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SOELLNER, MATTHEW B
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MICHIGAN AT ANN ARBOR
Exquisitely selective turn-on probes of kinase activation and localization Protein kinase-mediated phosphorylation is a vital posttranslational modification in eukaryotic cell signaling.Efforts to understand these complex signaling pathways have been hamp