Engineered regulation of tyrosine phosphatase activity in living cells


Year of Award:
2017
Award Type:
R21
Project Number:
1R21CA212907-01A1
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KARGINOV, ANDREI V
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF ILLINOIS AT CHICAGO
Aberrant signaling by protein tyrosine phosphatases (PTPases) has been identified for multiple cancers.However, dissection of PTPase-mediated signaling pathways that drive oncogenesis is limited by thecapabilities of current tools. It remains difficult to