NANOELECTRODE ARRAYS FOR STUDY OF THE MOLECULAR MECHANISMS, TRIGGERS, AND INHIBIT


Year of Award:
2010
Award Type:
R21
Project Number:
CA143351
RFA Number:
RFA-CA-09-008
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BURKE, PETER J.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CALIFORNIA-IRVINE
Mitochondria are the central regulator of apoptosis, a process initiated by the activation of the mitochondrial permeability transition pore (mtPTP), an aggregate of several mitochondrial proteins. When this pore opens, the critical membrane polarization