SPATIAL, HIGH-ACCURACY, MULTIPLEXED MAPPING OF GENES IN HUMAN TISSUE SECTIONS


Year of Award:
2009
Award Type:
R21
Project Number:
CA140068
RFA Number:
RFA-CA-08-006
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SHAPIRO, BENJAMIN
Other PI or Project Leader:
SMELA, ELISABETH
Institution:
UNIV OF MARYLAND, COLLEGE PARK
The aim of the proposed research is to demonstrate a technology to visualize the spatial distribution of genes and gene methylation in tissue sections. Our novel approach combines the key advantages of existing techniques: the amplification of in-situ PCR