MAPPING THE ARCHITECTURE OF CANCER SIGNALING PATHWAYS


Year of Award:
2009
Award Type:
R21
Project Number:
CA140030
RFA Number:
RFA-CA-08-007
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SODERLING, SCOTT H.
Other PI or Project Leader:
N/A
Institution:
DUKE UNIVERSITY
To appreciate how cells migrate, establish polarity, and adopt cell shape is fundamental to understanding cancer biology. Almost one percent of the human proteome is dedicated to Rho GTPase signaling, which regulates key aspects of each of these processes