IMAGING DNA DAMAGE DYNAMICS FOR DIAGNOSTICS, SCREENING AND TARGET DISCOVERY


Year of Award:
2009
Award Type:
R21
Project Number:
CA138365
RFA Number:
RFA-CA-08-006
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KRON, STEPHEN J.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CHICAGO
Radiation remains an important treatment modality in the therapy of breast cancer. Ionizing radiation induces DNA double strand breaks, which initiates a characteristic response. ATM and related protein kinases recognize each break and phosphorylate adjac