EPIGENETIC PROFILING BY NEAR-FIELD UV-RAMAN SCATTERING IN NANOCHANNELS


Year of Award:
2009
Award Type:
R21
Project Number:
CA132075
RFA Number:
RFA-CA-08-006
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
RIEHN, ROBERT
Other PI or Project Leader:
HALLEN, HANS
Institution:
NORTH CAROLINA STATE UNIVERSITY RALEIGH
Epigenetic programming has emerged as a central theme in cancer development. Here we propose a new technique for monitoring the methylation state, chromatin status, and histone modification of genomic sized molecules, ideally whole chromosomes. The propos