USING NEW OPTICAL TECHNIQUES TO STUDY CELL SIGNALING IN 3D MATRICES


Year of Award:
2008
Award Type:
R21
Project Number:
CA126635
RFA Number:
RFA-CA-07-035
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KEELY, PATRICIA J
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF WISCONSIN-MADISON
Mammary epithelial cells undergo ductal morphogenesis only in compliant 3D extracellular matrices (floating collagen gels or Matrigel), but not in otherwise identical matrices that are stiff (attached 3D collagen gels) or have increased collagen density.