UNIVERSAL TECHNOLOGY FOR PROFILING THE DYNAMICS OF NORMAL & ONCOGENIC SIGNALING


Year of Award:
2007
Award Type:
R21
Project Number:
CA125284
RFA Number:
RFA-CA-07-019
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ANDERSON, KAREN S
Other PI or Project Leader:
N/A
Institution:
YALE UNIVERSITY
Receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) are essential in the initiation of many protein signaling pathways. Dynamic control of multiple phosphorylation modifications of a single RTK thus can manifest critical contr