Year of Award:
2007
Status:
Complete
Award Type:
R21
Project Number:
CA125284
RFA Number:
RFA-CA-07-019
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ANDERSON, KAREN S
Other PI or Project Leader:
N/A
Institution:
YALE UNIVERSITY
External Link:
http://projectreporter.nih.gov/project_info_details.cfm?aid=7291179
Receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) are essential in the initiation of many protein signaling pathways. Dynamic control of multiple phosphorylation modifications of a single RTK thus can manifest critical contr