A NUCLEOSOMAL BIOSENSOR FOR IDENTIFICATION AND ISOLATION OF NUCLEAR HORMONE RECEP


Year of Award:
2007
Award Type:
R21
Project Number:
CA125514
RFA Number:
RFA-CA-07-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
STEINMAN, RICHARD A
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Nuclear hormone receptors (NHRs) modulate transcription by binding small lipophilic ligands and have a profound impact on normal cellular function and on development. Aberrant NHR function occurs frequently in cancers. This has prompted the development of