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MAPPING EPIGENETIC MODIFICATIONS AT THE NANOSCALE: APTAMERS FOR MICROSCOPY


Year of Award:
2007
Status:
Complete
Award Type:
R21
Project Number:
CA125510
RFA Number:
RFA-CA-07-015
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LINDSAY, STUART
Other PI or Project Leader:
N/A
Institution:
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
We propose to develop a technique for mapping post-translational chemical modifications of histones in chromatin by direct imaging of single molecules. Our approach is to use a new imaging mode for the atomic force microscope (AFM) that allows chemical co