FLUORESCENT ACTIVITY SENSORS IN ANALYSIS OF ONCOGENIC P13K/AKT SIGNALING


Year of Award:
2006
Award Type:
R21
Project Number:
CA122673
RFA Number:
RFA-CA-06-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ZHANG, JIN
Other PI or Project Leader:
N/A
Institution:
JOHNS HOPKINS UNIVERSITY
Activation of phosphatidylinositol 3-kinase (PI3K) and the downstream serine/threonine kinase Akt (also known as protein kinase B) triggers a cascade of responses that are critical for tumorigenesis, from cell growth and proliferation to survival and mobi