Year of Award:
2006
Status:
Complete
Award Type:
R21
Project Number:
CA123018
RFA Number:
RFA-CA-06-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SHI, HUIDONG
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MISSOURI-COLUMBIA
External Link:
http://projectreporter.nih.gov/project_info_details.cfm?aid=7136805
Hypermethylation of promoter CpG islands plays a prominent role in cancer. In partnership with alterations in histone acetylation/methylation, this epigenetic event establishes a repressive chromatin structure that leads to silencing of key cancer-related