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EPIGENETIC TARGETING IN NON-HODGKIN'S LYMPHOMA


Year of Award:
2006
Status:
Complete
Award Type:
R21
Project Number:
CA123018
RFA Number:
RFA-CA-06-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SHI, HUIDONG
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MISSOURI-COLUMBIA
Hypermethylation of promoter CpG islands plays a prominent role in cancer. In partnership with alterations in histone acetylation/methylation, this epigenetic event establishes a repressive chromatin structure that leads to silencing of key cancer-related