CHARACTERIZATION OF METHODS FOR PRESERVATION OF PHOSPHOPROTEINS IN FIXED TISSUES


Year of Award:
2006
Award Type:
R21
Project Number:
CA123006
RFA Number:
RFA-CA-06-004
Technology Track:
Biospecimen Science Technologies
PI/Project Leader:
HSI, ERIC
Other PI or Project Leader:
N/A
Institution:
CLEVELAND CLINIC LERNER COL/MED-CWRU
Protein phosphorylation is an important mechanism of regulating protein function and activity that depends on a competing system of kinases and phosphatases. It is a dynamic processes that is altered in many disease states. For example, activated tyrosine