GENETIC METHODS FOR DETECTING GAP JUNCTION COMMUNICATION


Year of Award:
2005
Award Type:
R21
Project Number:
CA111993
RFA Number:
RFA-CA-05-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WYMAN, ROBERT J
Other PI or Project Leader:
N/A
Institution:
YALE UNIVERSITY
There is strong evidence that gap junctional communication (GJC) is a regulator of cell proliferation and that interruption of this is one of the steps in the malignant transformations of cancer. Gap junctions occur in all animal species and in most tissu