IN VIVO GENE EXPRESSION IMAGING FOR CANCER ANALYSIS


Year of Award:
2003
Award Type:
R41
Project Number:
CA103103
RFA Number:
PAR-01-105
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SANTANGELO, PHILIP J
Other PI or Project Leader:
N/A
Institution:
VIVONETICS, INC.
We propose to develop a novel dual FRET molecular beacons technology for the early detection of cancer in living cells with high specificity, sensitivity and efficiency. Molecular beacons (MBs) are single-stranded oligonucleotides with a stem-loop hairpin