ERROR-FREE DNA AMPLIFICATION FOR MUTATION DETECTION


Year of Award:
2003
Award Type:
R21
Project Number:
CA102949
RFA Number:
PAR-01-104
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MAKRIGIORGOS, G. MIKE
Other PI or Project Leader:
N/A
Institution:
DANA-FARBER CANCER INSTITUTE
High selectivity mutation detection, which frequently relies on PCR, often falls short by 1-2 orders of magnitude of the selectivity required to identify cancer cells at an early stage, to investigate mechanisms of tumorigenesis, to detect mutations in si