BCR-ABL KINASE ASSAYS FOR STI571 SENSITIVITY OF RESPONSE


Year of Award:
2003
Award Type:
R21
Project Number:
CA103235
RFA Number:
PAR-01-104
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KRON, STEPHEN J.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CHICAGO
This phased innovation award proposal is focused on developing a robust approach to quantitative assay of specific protein tyrosine kinase activities from cancer cells. Our model is the oncogenic BCR-ABL fusion protein, the gene product of the t(9;22) Phi