PROTEIN KNOCKOUT TECHNOLOGY/MOLECULAR ANALYSIS OF CANCER


Year of Award:
2002
Award Type:
R33
Project Number:
CA092792
RFA Number:
PAR-99-102
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ZHOU, PENGBO
Other PI or Project Leader:
N/A
Institution:
WEILL MEDICAL COLLEGE OF CORNELL UNIV
The ubiquitin-proteasome pathway is a major cellular proteolysis machinery that selectively targets cellular proteins for degradation. Protein knockout, a new technology we recently developed, harnesses the specificity of the ubiquitin proteolytic system