PROFILING TUMOR CELLS BY SH2 DOMAIN BINDING PATTERN


Year of Award:
2002
Award Type:
R21
Project Number:
CA094378
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MAYER, BRUCE J
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
This proposal describes a novel proteomic method to profile cells on the basis of their binding; sites for Src Homology 2 (SH2) domains. This molecular diagnostic approach takes advantage of a basic signal transduction mechanism whereby cells receive info