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NOVEL TOOL FOR ANALYSIS OF PROMOTER HYPERMETHYLATION


Year of Award:
2002
Status:
Complete
Award Type:
R21
Project Number:
CA094441
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HUANG, TIM H.-M.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MISSOURI-COLUMBIA
We propose to develop a novel DNA chip specifically for high-throughput analysis of promoter hypermethylation in primary tumors. It is now clear that abnormal DNA methylation frequently occurs in multiple promoter CpG islands in cancer cells. Increased de