NEOPLASIA AND METHYLATED CPG ISLANDS AMPLIFICATION


Year of Award:
2002
Award Type:
R33
Project Number:
CA089837
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ISSA, JEAN-PIERRE J
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF TEXAS MD ANDERSON CAN CTR
CpG island methylation and associated gene silencing has been recognized as a very common event in human neoplasia, with potential to functionally contribute to tumor formation and progression. It has recently become apparent that CpG island methylation e