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MICROARRAY TECHNOLOGY TO PROFILE CPG ISLAND METHYLATION


Year of Award:
2002
Status:
Complete
Award Type:
R21
Project Number:
CA091351
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
FUTSCHER, BERNARD W
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF ARIZONA
The long-term objective of this research project is to adapt microarray-based technology to measure CpG island methylation in human cancer cells. CpG islands are approximately 1kb stretches of DNA that have a high CG content, are enriched in the dinucleot