GENOME-BASED TARGETING OF THE HEDGEHOG PATHWAY IN CANCER


Year of Award:
2002
Award Type:
R33
Project Number:
CA095957
RFA Number:
PAR-01-104
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BEACHY, PHILIP A
Other PI or Project Leader:
N/A
Institution:
JOHNS HOPKINS UNIVERSITY
Advances in cancer therapeutics have occasioned a strategic shift away from generally cytotoxic drugs toward agents that specifically target tumor cells by modulating the pathways or processes that are inappropriately regulated in the tumor. Despite this