DNA DAMAGE QUANTITATION BY SINGLE MOLECULE LASER SIZING


Year of Award:
2002
Award Type:
R33
Project Number:
CA088335
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SUTHERLAND, JOHN CLARK
Other PI or Project Leader:
N/A
Institution:
BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
Using single-molecule sizing by laser-induced fluorescence from DNA moving through a microfabricated channel, this project will develop novel technologies for quantifying DNA damage produced by ionizing radiation and other carcinogens. Damages include DN