CATION LABELING MASS SPECTROMETRY OF DNA ADDUCTS


Year of Award:
2002
Award Type:
R33
Project Number:
CA084641
RFA Number:
PAR-98-067
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
GIESE, ROGER WALLACE
Other PI or Project Leader:
N/A
Institution:
NORTHEASTERN UNIVERSITY
We propose new methodology based on chemical labeling and mass spectrometry (MS) for the discovery and qualitative analysis of unknown DNA adducts in human samples. Novel, bulky, nonpolar cationic reagents will be synthesized and tested as labeling reagen