TECHNOLOGY TO DETECT GENOME WIDE DNA METHYLATION CHANGES


Year of Award:
2001
Award Type:
R21
Project Number:
CA084704
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
YAMAMOTO, FUMIICHIRO
Other PI or Project Leader:
N/A
Institution:
BURNHAM INSTITUTE FOR MEDICAL RESEARCH
Somatic epigenetic alterations in DNA methylation are tightly linked to development, cell differentiation and neoplastic transformation. For instance, hypermethylation of CpG islands in promoter regions has been increasingly associated with transcriptiona