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MECHANISMS OF GENOMIC INSTABILITY IN CANCER


Year of Award:
2001
Status:
Complete
Award Type:
R21
Project Number:
CA091267
RFA Number:
PAR-99-100
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WATT, PAUL M
Other PI or Project Leader:
N/A
Institution:
TELETHON INSTITUTE FOR CHILD HEALTH RES
A breakdown in the maintenance of genome stability is an invariant feature of tumor cells and one of the defining features of the transformed phenotype. Much of the work on genome stability has focussed on the role of 'mutator' genes, which when themselv