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FLUORESCENCE DETECTION OF GENETIC INSTABILITY IN MICE


Year of Award:
2001
Status:
Complete
Award Type:
R33
Project Number:
CA084740
RFA Number:
PAR-98-067
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ENGELWARD, BEVIN P.
Other PI or Project Leader:
N/A
Institution:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Recombinational repair protects against the cytotoxic effects of DNA damaging agents. However, a side effect of mitotic recombination is that it can also promote deletions and gene conversion events that contribute to tumorigenesis. Thus, it is critical