DNA MISMATCH REPAIR FUNCTIONAL GENETIC TESTS


Year of Award:
2001
Status:
Complete
Award Type:
R44
Project Number:
CA081965
RFA Number:
PAR-99-101
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BITTER, GRANT A.
Other PI or Project Leader:
N/A
Institution:
BITTECH, INC.
Genomic instability is associated with cancer progression, and defects in DNA mismatch repair (MMR) is one pathway leading to genomic instability. Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in genes encoding proteins involved