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HIGH THROUGHPUT METHYLATION ANALYSIS IN CANCER


Year of Award:
2000
Status:
Complete
Award Type:
R33
Project Number:
CA084701
RFA Number:
PAR-98-067
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HUANG, TIM H.-M.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MISSOURI-COLUMBIA
Aberrant DNA methylation frequently occurs in CpG islands, which are 0.2 to 2-kb GC-rich sequences located in the 5 ends of approximately 60 percent of all genes, in neoplasia. This type of epigenetic mutation is associated with the silencing of tumor sup