DNA MISMATCH REPAIR FUNCTIONAL GENETIC TESTS


Year of Award:
1999
Award Type:
R43
Project Number:
CA081965
RFA Number:
PAR-98-066
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BITTER, GRANT A.
Other PI or Project Leader:
N/A
Institution:
BITTECH, INC.
Genomic instability has been well documented in both cancer cells and precancer cells. Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in any one of four genes encoding proteins involved in DNA mismatch repair (DMR). Defects in DM