Bevin P. Engelward, Ph.D.
Massachusetts Institute of Technology
- IMAT Award: Applications of “Recombomice” for Cancer Research (R33)
- Technology: Created and engineered a substrate capable of yielding fluorescence at recombination, thereby engineering the first mouse model in which homology-directed repair (HDR) can be detected in somatic cells by the appearance of a fluorescent signal.
Impact: Increased simplicity and rapidity of recombinant assays capabile of overcoming limitations imposed by previous model systems including detection of loss of heterozygosity; capturing in situ images of recombined cells and discrimination of independent lineages of recombinant cells in vivo.
- Award-Related Publications and Citations: 27 PubMed publications; 5 on flourescent imaging; 8 with a focus on cancer.
- Patent: Radiation-induced cellular adaptive response (pending)
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