Rudolf Aebersold, Ph.D.
Institute for Systems Biology
- IMAT Award: Isotope Coded Affinity Tags (ICAT) for Quantitative Proteomics (2000)
- Technology: Developed a new class of reagents termed isotope-coded affinity tags (ICAT) that selectively reacts and isotopically labels cysteine residues in proteins (Gygi, Rist et al. 1999). Combining the ICAT technology with mLC-MS/MS and database searching allows the identify and accurately quantify individual proteins within complex mixtures to be done simultaneously (Gygi, Rist et al. 1999).
Impact: Large-scale analysis of complex samples, including whole proteomes and small-scale analysis of sub-proteomes made possible.
- PubMed: 218 publications on ICAT technology with over 1,000 citations. 34 with focus on cancer.
- Patents:
- Methods for Isolating and Labeling Sample Molecules (Granted, Patent 7,183,116)
- Methods for High Throughput and Quantitative Proteome Analysis (Pending)
- Methods for Rapid and Quantitative Proteome Analysis (Pending)
- Androgen-Regulated Genes and Uses for Diagnosis, Prognosis and Treatment of Prostate Neoplastic Conditions (Pending)
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